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Development and Implementation of a Sustainable Modelling Platform for NanoInformatics.

Development and Implementation of a Sustainable Modelling Platform for NanoInformatics.

Objective

NanoInformaTIX aims to create a comprehensive, sustainable, multi-scale modelling framework for exposure and (eco)-toxicity of Engineered Nanomaterials (ENM) to facilitate cost-effective risk assessment, less reliant on animal testing, and to support the design of safer materials and products. Our approach integrates several relevant EU/US databases with validated nanoinformatics models covering: Materials, Exposure, Physiologically-Based Pharmacokinetics (PBPK), Quantitative-Structure-Activity Relations (QSAR) and Systems Biology modelling and in vitro/in vivo extrapolation to support the prediction of biological effects and exposure of ENM at various stages of their life cycle and product development. NanoInformaTIX will address grouping and read-across for risk assessment and safer product design. NanoInformaTIX will use existing curated data from several completed EU/US projects and from peer-reviewed literature to develop, extend the models and will also consider emerging data from ongoing projects for model validation following the OECD validation principles. This will take the NanoInformaTIX models from TLR4 to TLR6. The NanoInformaTIX modelling framework will be a web-based platform with a user-friendly interface tailored to the needs of different stakeholders (industry, regulators, academia and the civil society). To obtain optimal confidence in the use of the NanoInformaTIX modelling and database framework, all models will be described clearly using agreed standards terminology and implemented on harmonized standard operating protocols based on Good Modelling/Software Design practices. Their applicability domain will be clearly documented and referenced for full transparency and detailed user guidance for each will be provided. NanoInformaTIX will achieve considerable impact by providing the much -needed validated accessible data management modelling framework to predict human and environmental risks, to support the design of sustainable ENM and products.
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Research Organisations

EU Contribution

€ 380 000

Participants (35)

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INSTITUTE OF OCCUPATIONAL MEDICINE

United Kingdom

EU Contribution

€ 223 360

EUROPEAN RESEARCH SERVICES GMBH

Germany

EU Contribution

€ 168 000

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 217 213,75

BUNDESINSTITUT FUER RISIKOBEWERTUNG

Germany

EU Contribution

€ 309 000

GREENDECISION SRL

Italy

EU Contribution

€ 101 812,50

THOMAS MORE KEMPEN VZW

Belgium

EU Contribution

€ 234 000

TEL AVIV UNIVERSITY

Israel

EU Contribution

€ 255 000

UNIWERSYTET GDANSKI

Poland

EU Contribution

€ 219 450

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 178 175

UNIVERSITAT ROVIRA I VIRGILI

Spain

EU Contribution

€ 233 993,75

IDEACONSULT LIMITED LIABILITY COMPANY

Bulgaria

EU Contribution

€ 239 125

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 300 875

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 350 000

SINTEF OCEAN AS

Norway

EU Contribution

€ 170 000

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA

Italy

EU Contribution

€ 188 750

NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA

Greece

EU Contribution

€ 163 750

UNIVERSIDADE DE AVEIRO

Portugal

EU Contribution

€ 222 750

EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT

Switzerland

EU Contribution

€ 233 617,50

UPPINTECH OU

Estonia

EU Contribution

€ 130 000

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Greece

EU Contribution

€ 148 750

POLITECNICO DI TORINO

Italy

EU Contribution

€ 234 375

WARRANT HUB SPA

Italy

EU Contribution

€ 233 000

TEMAS AG TECHNOLOGY AND MANAGEMENT SERVICES

Switzerland

EU Contribution

€ 238 750

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 159 363,75

DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO

Denmark

EU Contribution

€ 114 750

TYOTERVEYSLAITOS

Finland

EU Contribution

€ 115 000

SWANSEA UNIVERSITY

United Kingdom

EU Contribution

€ 284 945

UNIVERSITE D'AIX MARSEILLE

France

EU Contribution

€ 100 000

MINTEK

South Africa

EU Contribution

€ 90 000

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ

Germany

EU Contribution

€ 140 000

EAST EUROPEAN RESEARCH AND INNOVATION ENTERPRISE LTD

Bulgaria

EU Contribution

€ 205 625

NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA

China

NATIONAL CHENG KUNG UNIVERSITY

Taiwan

SORBONNE UNIVERSITE

France

EU Contribution

€ 120 000

UNIVERSITE CATHOLIQUE DE L'OUEST ASSOCIATION SAINT YVES

France

EU Contribution

€ 80 125

Project information

Grant agreement ID: 814426

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    28 February 2023

Funded under:

H2020-EU.2.1.3.

H2020-EU.2.1.2.

  • Overall budget:

    € 7 751 271,25

  • EU contribution

    € 6 783 556,25

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain