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Cellular modulation by the mitochondrial unfolded protein response

Project description

Mitochondrial protein misfolding and the restoration of proteostasis

Many diseases, including cancer and neurodegenerative diseases, affect mitochondrial function and proteostasis, a poorly characterised pathway in mammalian cells. In the case of protein misfolding, mitochondria activate the mitochondrial unfolded protein response (UPRmt) to restore proteostasis. The EU-funded mitoUPR project addresses the regulation of this pathway using tools to induce the UPRmt in mammalian cells combined with quantitative mass spectrometry, microscopy, next-generation sequencing and gene editing. Moreover, it investigates the influence the UPRmt exerts on the environments of mitochondria, cytosol and neighboring cells. The project aims to uncover a novel layer of cellular stress regulation associated with the UPRmt pathway.

Call for proposal

ERC-2018-STG
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Host institution

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 437 500

Beneficiaries (1)

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 1 437 500
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments