Project description
Probing the association between lactase persistence and microbes in dairy cultures
The origin and role of dairying in early human societies are poorly understood. Few human populations can digest the lactose in milk into adulthood (lactase persistence – LP), while most adult humans have a reduced ability to digest this milk sugar. LP was considered a classic example of gene–culture co-evolution. However, the association between LP and lactose intolerance phenotypes is variable, and growing evidence points to the role of microbes in prehistoric dairying economies. Focusing on Mongolia, a country where diet largely comprises dairy products, the EU-funded DAIRYCULTURES project will apply innovative genomics techniques to identify the origins of local dairy livestock and test hypotheses concerning the connection between gut microbiome, lactose digestion and LP genotypes.
Objective
Summary: Dairy products are nutritional resources of global economic importance, and their emergence in prehistory marks a major shift in human dietary ecology. However, basic questions regarding the origins and role of dairying in early human societies remain poorly understood. It is now known that adult hypolactasia (the inability to digest milk sugar) is an ancestral human trait, and that relatively few human populations have genetic variants that allow continued milk digestion into adulthood, a trait known as lactase persistence (LP). The rise of LP has been regarded as a classic example of gene-culture evolution; however, the association between LP and lactose intolerance phenotypes is variable, and LP genotypes do not consistently appear in the archaeological record until more than 5,000 years after the origins of dairying. This has left archaeologists with a puzzling problem, a “milk paradox” regarding how and why ancient peoples developed milk into a dietary resource, how the Bronze Age steppe migrations contributed to the spread of dairying across Eurasia, and what other factors besides LP may have been involved this process. There is now a growing body of evidence that microbes have played important, yet overlooked, roles in the successful establishment of prehistoric dairying economies. This study seeks to answer fundamental questions about the prehistory of dairying by focusing on Mongolia, a country where as much as 80% of the rural diet derives from dairy products, and where dairying has been practiced for more than 3,500 years. Specifically, cutting-edge genomics techniques will be used to identify the origins of Mongolian dairy livestock, proteomics techniques will be used to refine methods for detecting milk proteins in archaeological Mongolian dental calculus, and metagenomics techniques will be used to test hypotheses regarding the relationship between the gut microbiome, lactose digestion, and LP genotypes in nomadic Mongolian dairy herders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history prehistory
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences nutrition
- agricultural sciences animal and dairy science domestic animals animal husbandry
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-STG
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80539 Munchen
Germany
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