Developing de novo proteins for bone regeneration
The successful regeneration of bone tissue to replace areas of bone loss remains a considerable clinical challenge. Efforts are concentrated on designing biomaterials using biomimetic strategies that use proteins from the extracellular matrix. Some of these proteins contain domains capable of binding growth factors, as in the case of the heparin binding II (HBII) domain of fibronectin that can bind bone morphogenetic proteins (BMPs). BMP-2 is a potent osteoinductive molecule. However, HBII lacks specificity for BMP-2. The EU-funded ENGAGE project will identify the hotspot sequences involved in HBII BMP-2 interaction and develop de novo proteins with high affinity to BMP-2 to further exploit them in hydrogel biomaterials to increase bone regeneration.
Fields of science
Funding SchemeMSCA-IF-GF - Global Fellowships
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
98195 9472 Seattle Wa
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