Project description
Chiral heterocyclic fluorophores: separating the wheat from the chaff
Many compounds can exist in multiple forms, having the same molecular formula but different structures (isomers). An important example of this isomerism is chiral molecules which are not superimposable on their mirror images. Many synthetic routes end up with so-called racemic mixtures containing both forms of a chiral molecule when only the one is desired. Such is the case with many fluorophores, small light-absorbing and -emitting molecules that are important to many fields. With the support of the Marie Skłodowska-Curie Actions programme, the AtropFluoPhoto project is developing a strategy for the selective catalytic synthesis of specific forms of chiral heterocyclic fluorophores and exploring their applications.
Objective
Arylated heterocyclic systems, such as fluorophores, have a long history as a component in functional materials. They are extremely useful platforms for a broad application in material science, biological imaging or organic synthesis, owing to their unique chemical, photophysical, and electrochemical properties. The development of an efficient route to prepare this type of heterocycles continues to attract interest for various applications, while only limited to the synthesis of symmetric fluorophores in racemic fashion. Introducing a chiral element into the molecules is of great significance for drug discovery, the design of catalysts for asymmetric synthetic photochemistry and other enantioselective methods. The resulting fluorophore bearing enantiospecific sensing platforms may also find potential applications in the enantioselective recognition of chiral small molecules or bioactive compounds such as DNA.
Hence, the aim of the proposed AtropFluoPhoto is to develop a strategy for the asymmetric catalytic synthesis of chiral heterocyclic fluorophores. We plan to investigate different activation modes, such as chiral Brønsted acid and anion-binding catalysis, to achieve the construction of axially chiral fluorophores in intramolecular or intermolecular reactions. With the knowledge of their unique chemical and photophysical properties, we will then particularly explore their practical application in synthesis and novel catalyst design for asymmetric catalysis in photocatalysis. The proposed research will greatly broaden the fellow´s competencies and help him reach the professional maturity for a future academic career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis photocatalysis
- natural sciences chemical sciences organic chemistry heterocyclic compounds
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4051 Basel
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.