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Transport derived Ultrafines and the Brain Effects

Transport derived Ultrafines and the Brain Effects

Objective

The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.

Coordinator

ITA-SUOMEN YLIOPISTO

Address

Yliopistonranta 1 E
70211 Kuopio

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 891 170

Participants (14)

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INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH

Germany

EU Contribution

€ 403 040

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 578 856

UMEA UNIVERSITET

Sweden

EU Contribution

€ 262 625

ILMATIETEEN LAITOS

Finland

EU Contribution

€ 220 000

Teknologian tutkimuskeskus VTT Oy

Finland

EU Contribution

€ 520 086

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU Contribution

€ 232 868

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 294 467

MIMETAS BV

Netherlands

EU Contribution

€ 400 393

BIOTALENTUM TUDASFEJLESZTO KFT

Hungary

EU Contribution

€ 361 875

TAMPEREEN KORKEAKOULUSAATIO SR

Finland

EU Contribution

€ 337 087

USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE

Czechia

EU Contribution

€ 337 772

SUN YAT-SEN UNIVERSITY

China

VSPARTICLE BV

Netherlands

EU Contribution

€ 110 887

CENTRO PREMIO NOBEL MARIO MOLINA PARA ESTUDIOS ESTRATEGICOS SOBRE ENERGIA Y MEDIO AMBIENTE CHILE LIMITADA

Chile

EU Contribution

€ 98 750

Project information

Grant agreement ID: 814978

Status

Ongoing project

  • Start date

    1 May 2019

  • End date

    30 April 2023

Funded under:

H2020-EU.3.4.

  • Overall budget:

    € 5 989 370

  • EU contribution

    € 5 049 876

Coordinated by:

ITA-SUOMEN YLIOPISTO

Finland