Descripción del proyecto
El impacto neurológico de la contaminación atmosférica
Hace mucho que se sabe que los contaminantes atmosféricos causan enfermedades respiratorias y cardiovasculares. Sin embargo, pruebas recientes indican una relación entre la contaminación atmosférica y algunos trastornos neurológicos como la enfermedad de Alzheimer. Para investigar más a fondo esta observación, el proyecto TUBE, financiado con fondos europeos, reunió a expertos de diversas disciplinas con la intención de estudiar el impacto inflamatorio, citotóxico y genotóxico de las partículas ultrafinas en los aerosoles de escape generados por distintos tipos de tráfico. Mediante el empleo de modelos «in vitro» y datos epidemiológicos, se investigarán los efectos de las partículas generadas por el tráfico sobre la neurotoxicidad y la salud encefálica, lo que allanará el camino para el desarrollo de nuevas estrategias de evaluación de riesgos.
Objetivo
The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.
Ámbito científico
- medical and health sciencesclinical medicinepneumologyasthma
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- engineering and technologyenvironmental engineeringair pollution engineering
- engineering and technologynanotechnologynano-materials
- medical and health sciencesbasic medicinetoxicology
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-MG-2018-TwoStages
Régimen de financiación
RIA - Research and Innovation actionCoordinador
70211 KUOPIO
Finlandia