Description du projet
Révéler l’impact neurologique de la pollution atmosphérique
Les polluants atmosphériques sont connus depuis longtemps pour causer des maladies respiratoires et cardiovasculaires. Cependant, des preuves récentes indiquent une relation entre l’air pollué et des troubles neurologiques comme la maladie d’Alzheimer. Pour approfondir cette observation, le projet TUBE, financé par l’UE, rassemble des experts dans diverses disciplines. L’objectif consiste à étudier l’impact inflammatoire, cytotoxique et génotoxique des particules ultrafines dans les aérosols d’échappement, générées par différents types de trafic. En utilisant à la fois des modèles in vitro et des données épidémiologiques, les chercheurs mettront l’accent sur les effets neurotoxiques et sur la santé cérébrale des particules générées par le trafic, ouvrant la voie à de nouvelles stratégies d’évaluation des risques.
Objectif
The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.
Champ scientifique
- medical and health sciencesclinical medicinepneumologyasthma
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- engineering and technologyenvironmental engineeringair pollution engineering
- engineering and technologynanotechnologynano-materials
- medical and health sciencesbasic medicinetoxicology
Mots‑clés
Programme(s)
Régime de financement
RIA - Research and Innovation actionCoordinateur
70211 KUOPIO
Finlande