Projektbeschreibung
Entschlüsselung der neurologischen Auswirkungen von Luftverschmutzung
Schon lange ist bekannt, dass Schadstoffe in der Luft Atemwegs- und Herz-Kreislauf-Erkrankungen verursachen. Jüngste Erkenntnisse weisen jedoch auf einen Zusammenhang zwischen schadstoffbelasteter Luft und neurologischen Erkrankungen wie der Alzheimer-Krankheit hin. Um diese Beobachtung genauer zu untersuchen, bringt das EU-finanzierte Projekt TUBE Fachleute aus verschiedenen Disziplinen zusammen. Ziel ist die Untersuchung der entzündlichen, zytotoxischen und genotoxischen Wirkung ultrafeiner Partikel im Abgas-Aerosol, das von verschiedenen Verkehrsarten erzeugt wird. Unter Verwendung von in vitro-Modellen und epidemiologischen Daten werden die Forschenden den Schwerpunkt auf die neurotoxischen und hirnmedizinischen Auswirkungen verkehrsbedingter Partikel setzen und so den Weg für neuartige Strategien zur Risikobewertung ebnen.
Ziel
The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.
Wissenschaftliches Gebiet
- medical and health sciencesclinical medicinepneumologyasthma
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- engineering and technologyenvironmental engineeringair pollution engineering
- engineering and technologynanotechnologynano-materials
- medical and health sciencesbasic medicinetoxicology
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenUnterauftrag
H2020-MG-2018-TwoStages
Finanzierungsplan
RIA - Research and Innovation actionKoordinator
70211 KUOPIO
Finnland