Project description
A synthetic library of DNA regulatory sites could help control gene expression
All somatic cells in an organism contain the entire genetic code for all the proteins the organism makes. However, gene expression in cells is highly regulated by repressor or activator proteins that bind to DNA, often close to the start site of transcription. Given the critical role of gene expression in normal development and functioning and in disease, the EU-funded UNILIB project has developed a new tool to study and manipulate it better. A synthetic library of DNA patterns representing regulatory binding sites conserved in organisms from yeast to mammals could unlock gene expression in a myriad of applications. UNILIB plans to demonstrate its capabilities and pave the way for maximum impact.
Objective
DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter is the focus of the MRG-GRammar H2020 FET project.
As part of the results of MRG-Grammar, we have developed a universal regulatory library that is made of binding sites motifs that have been shown to be highly active in every cell type that we have tested from yeast to mammalians. The library is synthesized with a new composite-base technology that was also developed in MRG-Grammar.
In this study, we propose to explore the application space for the universal library and resultant market potential. Requested funding will be used to complete the universal library proto-type and to demonstrate that expression of a biologic can be optimized with this tool. In addition, we will explore a potential service model, business model, and a licensing mechanism for the dissemination of the universal library for various stake-holders in the academia and private sectors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- social sciences economics and business business and management business models
- agricultural sciences agriculture, forestry, and fisheries agriculture
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
MAIN PROGRAMME
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H2020-EU.1.2.1. - FET Open
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
CSA - Coordination and support action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-FETOPEN-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.