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Visualizing Death Inducing Protein Complexes

Objective

Every day billions of cells die in our bodies as part of normal healthy processes. These cell deaths are called “regulated cell deaths” as they occur through the activation of genetically encoded molecular machinery. However, too little or too much cell death is the cause of various diseases and of illness caused by exposure to chemicals. Understanding these cell death processes and how they are controlled may lead to new treatments for disease as well as explaining why some chemicals are hazardous.

Regulated cell deaths as exemplified by apoptosis, necroptosis, and pyroptosis are induced by the formation of protein complexes. Here, we will develop new molecular tools to visualize the formation of the protein complexes in live cells and tissues and then use these tools to study cell death in normal and disease processes. Our consortium includes cell death experts, bioluminescence experts, zebrafish experts, as well as structural, developmental, molecular and cell biologists in industry and academia. The proposed research network will provide intersectoral mobility between laboratories expert in complementary skills. This will drive the development of the new tool and enhance the researchers’ career prospects.

The research is of importance to many citizens of the EC; it will contribute to increasing food security by improving aquaculture, improving the health of aging populations through the study of degenerative diseases, improving toxicity assessment to better protect citizens from chemical hazards and improving the drug-development by better identification of adverse effects. Moreover, the assays emerging from the research will be commercialized by the industrial partners in the network, so supporting economic development within the EU.

Call for proposal

H2020-MSCA-RISE-2019
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 312 800

Participants (7)

GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 55 200
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 101 200
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
PROTOQSAR 2000 SL
Spain
EU contribution
€ 69 000
Address
C Salvador Ferrandis Luna 45 Pta 23
46018 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZECLINICS SL
Spain
EU contribution
€ 184 000
Address
Ctra De Can Ruti, Cami De Les Escoles, S/n Laboratori P0-8, Edifici Igtp Muntanya
08916 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
EU contribution
€ 303 600
Address
Universitetstunet 3
1433 As
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 18 400
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 193 200
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations

Partners (2)

TARBIAT MODARES UNIVERSITY (INSTRUCTOR'S TRAINING UNIVERSITY)
Iran
Address
Intersection Of Shahid Chamran And Jalal Al Ahmad Highway
14115 175 Tehran
Activity type
Higher or Secondary Education Establishments
OLYMPUS CORPORATION
Japan
Address
2915 Ishikawa-machi
192-8507 Hachioji-shi Tokyo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)