Project description
A shorter path for the synthesis of polycyclic terpenes
Xanthates comprise a class of organic salts formed by the treatment of an alcohol with carbon disulfide in the presence of an alkali. These organosulphur compounds are versatile intermediates in organic synthesis. The EU-funded Route2polyTepr project will demonstrate how xanthates could significantly shorten the synthesis path of synthetic polycyclic terpenes and terpene alkaloids. Xanthates enable the formation of new carbon–carbon bonds on unactivated alkenes as well as the formation of rings that are impossible to achieve with other methods. The project will generate new knowledge on xanthates' potential in radical reactions (powerful carbon–carbon bond-forming processes).
Objective
In this proposal we would like to demonstrate the strategic role that xanthates could play in providing a unified approach to a multitude of polycyclic terpenes and in shortening considerably the synthetic routes. By enabling the strategic intermolecular creation of new carbon-carbon bonds on unactivated alkenes and the formation of rings not readily accessible by other methods, the degenerative radical exchange of xanthates opens numerous synthetic avenues not hitherto available. Unusual retrosynthetic disconnections will now be envisaged, and it is hoped that a unified, short, and practical route to numerous classes of polycyclic terpenes and terpene alkaloids can be implemented. Demonstration of the advantage of using xanthate transfer to the synthesis of polycyclic terpenes will bring the academic’s attention to novel applications of radical reactions, promoting the development in the area.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91128 PALAISEAU CEDEX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.