Project description
An exosome detection platform for cancer diagnosis
Liquid biopsy is a non-invasive approach for personalised cancer diagnosis and relies on circulating tumour cells and tumour DNA. However, extracellular vesicles termed exosomes are emerging as promising biomarkers for prompt cancer detection. To facilitate routine exosome analysis in the clinic, scientists of the EU-funded IMPED project propose to develop a next-generation technology capable of extracting and analysing exosomes from liquid biopsies or serum samples at the proteomic and genomic levels. The technology will be the first to combine both intra- and extra-vesicle detection on a single platform, offering important insight into precision cancer management on an individual patient basis.
Objective
In order to adapt treatment to the multicity of cancer types, cancer patient management has been revolutionized in the past decades by personalized medicine. As part of this strategy, liquid biopsy has emerged as a non-invasive approach for personalized diagnostics and treatment. So far, this approach has focused on circulating tumor cells and circulating tumor DNA. However, extracellular vesicles termed exosomes, which are implicated in cellular communication and molecule transfer, have risen as promising biomarkers for earlier and more accurate detection. The IMPED project aims at developing a next-generation technology able to extract and analyse single exosomes or sub-groups of exosomes on both the proteomic and genomic level. This platform will offer beyond state-of-the-art information on the involvement of exosomes in cancer development. It has the potential to increase the precision of liquid biopsy analysis and provide clinically relevant insight for personalized cancer management. Toward this goal, the IMPED project will gather three technologies allowing low-cost extraction and analysis of exosomes from human plasma: (1) Continuous label-free extraction of exosomes from complex matrices (plasma) using thermophoresis (2) Proteomic profiling of single exosomes immobilized on a nanoarray with possibility of release (3) Droplet-based reverse transcriptase polymerase chain reaction (RT-PCR) of exosomes for RNA content analysis To our knowledge, this would be the first technology to couple intra- and extra-vesicle detection on a single/subpopulation exosome level within a single platform. The IMPED project is interdisciplinary, connecting physics, microfluidics and bioassay development for biomedical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
- medical and health sciences health sciences personalized medicine
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.