Project description
Probiotics for groundbreaking oral hygiene
Oral health prevents caries and periodontal diseases and tooth loss. It’s also important for our overall health and well-being. However, billions of people worldwide do not have access to affordable oral care, which the World Health Organization says is a priority. Effective prevention based on balanced treatment of oral microbiota could be an answer. In this direction, the EU-funded SMILES project proposes a cost-effective preventive solution through the development of cocktails with biomedical application that will be based on specific characteristics of the antimicrobial peptides produced by Streptococcus dentisani, a probiotic bacterium. This will enable new widely accessible products to prevent diseases resulting from microbial dysbiosis.
Objective
Billions of people suffer from oral diseases world-wide while oral health treatments are not affordable for everyone. Goal 3 of the United Nations Sustainable Development challenge/priority programs, to be reached by 2030, is to promote “access to quality essential health-care services and access to safe, effective, quality and affordable essential medicines [..] for all”. The WHO points therefore towards cost-effective oral disease prevention as a key strategy to reach a universal health care access. The main scientific objective of SMILES is identifying, characterizing, and harnessing antimicrobial peptides (AMPs) produced by Streptococcus dentisani and select cocktails with biomedical application in the treatment of caries and periodontitis. S. dentisani is a probiotic bacterium which produces AMPs, and which is naturally found in oral disease-free individuals maintaining the balance for a healthy oral microbiota. Caries and periodontitis are two oral diseases resulting from microbial dysbiosis. These cocktails could be incorporated in the future as additives in conventional oral hygiene products (ex. toothpaste), as oral disease preventive agents accessible for the public independently of their monetary resources. Dr. Revilla-Guarinos has expertise in antimicrobial resistance and will lead SMILES. The research and training at the academic host institution will be complemented with an intersectoral secondment in DENTAID (an oral health care products leading company), international networking & collaborations, specialized training courses & complementary skills workshops. Dissemination & exploitation activities, as well as communication & outreach events will promote the action and its results. The overarching ambition of this action is training and preparing Dr. Revilla-Guarinos for her to start her own group in academia or, alternatively, to develop a new path by changing to a career in industry, working at the forefront of Applied Microbiology in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
46010 Valencia
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.