Project description
Investigation of mTORC2 protein complex in lung cancer model
mTOR Complex 2 (mTORC2) is a protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation, survival, migration, and cytoskeletal remodelling. mTORC2 plays a crucial role in metabolic regulation and can be linked to many human pathologies. The EU-funded TransMetTOR project aims to investigate the role of mTORC2 in mRNA translation and cellular metabolism in lung cancer development. The project will employ a combination of cutting-edge omics approaches and involve the characterisation of unique mouse models generated in the host lab. The goal is to decipher the molecular mechanisms that sustain mTORC2-dependent metabolism and provide innovative strategies to target mTORC2 signalling in lung cancer.
Objective
The aim of this project to investigate the role(s) of mTORC2 in mRNA translation and cellular metabolism, in the context of lung cancer development. This work will be carried out in the laboratory of Dr. Pierre Close, at the GIGA-Uliège, who made seminal discoveries in the field of translation regulation and cancer biology. This ambitious project will bring an opportunistic synergy between the expertise in cancer metabolism of the researcher, Dr. Blomme, and the knowhow in translation regulation of the host laboratory. In addition, the project relies on the combination of cutting-edge unbiased “omics” approaches and involves the characterisation of unique mouse models recently generated in the host lab. It is further supported by four high-profile international collaborations that will provide essential technical expertise in metabolomics and lipidomics, and support the clinical aspects of the proposal. As part of an interdisciplinary training, Dr. Blomme will carry out a secondment in the translational research group of Prof. Vooijs, at Maastricht University, in order to learn ex-vivo organoid models of lung cancer. The proposed project addresses fundamental questions of cell biology in a highly clinically relevant context. As such, it holds the potential to result in the design of future anticancer therapeutic strategies. Indeed, the mTORC2 pathway is very often dysregulated in lung cancer. Therefore, by deciphering the molecular mechanisms that sustain mTORC2-dependent metabolism, this work will provide innovative strategies to target mTORC2 signalling in lung cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology cell metabolism
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4000 LIEGE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.