Project description
Soft bioelectrochemical model of electron transport chain
Cells contain protein molecular motors that help them produce energy and motion as well as transport cargoes. Disruptions to the mitochondrial electron transport chain (ETC), an energy-producing system, lead to cancer, neurodegeneration and heart failure. Soft electrified interfaces such as membranes for ion-selective electrodes, biomembranes and liquid–liquid interfaces belong to the class of electrochemical interfaces. Funded by the Marie Skłodowska-Curie Actions programme, the SoftBioArt project is developing model membrane systems to be used as scaffolds for the proteins and enzymes of the ETC at electrified soft interfaces, maximising electron transfer efficiency. The researchers will explore a new paradigm in ETC by achieving efficient inter-protein electron transfer and applying this bioelectrochemical platform to identify possible electron leakage points associated with ETC malfunctions.
Objective
All cells contain tiny molecular motors made from a large family of proteins including enzymes and antibodies that help the cell produce energy, move, and move material inside the cell. While several biomolecular motors have been identified, the remaining challenges are determining how these species transfer information from one region of a motor to another and how the malfunctioning of these can lead to the development of several diseases. One timely example is the detrimental effect that a disrupted mitochondrial electron transport chain (ETC) can produce in human beings (e.g. cancer, neurodegeneration, heart failure). The SoftBioArt project will explore a new paradigm in ETC by achieving an efficient inter-protein electron transfer at electrified soft-interfaces and to using this platform to pinpoint any weak points for possible electron leakage during the ETC. The SoftBioArt program will result in a new platform bringing biomimetic modified soft-interfaces to a new level, to demystify one of the most relevant living machines within mitochondria (respiratory ETC) where any malfunctioning is linked to the development of several chronic human diseases. Thus, the SofBioArt program will develop model membrane systems that will serve as scaffolds harbouring protein and enzymes of the ETC at soft-interfaces maximizing the electron transfer efficiency at an electrified soft-interface. The SoftBioArt project pushes the boundaries of the current state-of-the-art of bioelectrochemistry at soft-interfaces to determine if this unexplored system can bridge the gap between solid electrode bioelectrochemistry and living systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences electrochemistry bioelectrochemistry
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine cardiology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
03690 Alicante
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.