Objective
I am a neuroscientist specialized on brain development and genetic brain disorders. During my PhD with Dr. Gaia Novarino (IST Austria) I developed a strong expertise in using in vivo mouse models and a large number of different techniques to investigate the underlying cause of intellectual disability and autism. My work helped to better understand the pathophysiologic mechanisms driving these complex neurodevelopmental conditions, as well as the process of brain development more in general. Now, I aim to expand my research profile to neurodegeneration and the non-coding genome, specifically circular RNAs (circRNA). As a postdoctoral researcher in the lab of Dr. Biagioli at Dep. CIBIO (UniTN) I seek to combine my strong background in functional in vivo studies with her outstanding expertise in Huntington`s Disease (HD) research and epigenetics to elucidate a novel regulatory pathway in HD. In this proposal, I designed a dedicated research and training plan that will significantly expand my scientific portfolio and uncover the in vivo functional role(s) of circHTT, a newly discovered circRNA molecule -discovered and initially characterized by Dr. Biagioli’s lab - stemming from the HD locus. We will study its mouse orthologue, circHtt, focusing on expression dynamics and pattern during development and aging and visualize its cellular and subcellular localization in the brain. We will analyse its relevance for HD pathology by using HD mouse models and uncover its molecular brain function(s) by exploiting the innovative and highly specific CRISPR-Cas13 knock-down machinery in vivo. The results of this project will highlight a novel regulatory network in HD pathophysiology in which circHTT may act as modifier of/or novel biomarker for HD progression, or represent a novel molecular drug target. This award is vital for me to return from maternity leave and join the Biagioli group. It will significantly contribute to my career perspectives inside and outside of academia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences basic medicine pathology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
38122 Trento
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.