Objective
Receptor ectodomain shedding (shedding) is a fundamental mechanism of the regulation of communication between mammalian cells. Shedding refers to the proteolytic cleavage of the extracellular portion of a membrane protein. This process can inactivate the function of a receptor, generate extracellular signalling molecules and trigger the generation of intracellular protein forms involved in signalling. Shedding is best understood in mammals, with hundreds of shedding events reported, but also occurs in other animals and fungi. A few cases of shedding have been observed in plants. Membrane receptor like kinases (RLKs) constitute the main players of cell-to-cell communication in plants, with many of them serving as key immune receptors. RLK shedding has been reported in two occasions, pointing to an important regulatory function. Despite the essential functions of shedding in animals, the biological significance of RLK shedding in plants, and the fact that plant cells harbour many more receptors than their animal counterparts, shedding has yet to be studied systematically in plants. By reanalysis of large scale extracellular proteome datasets, I found evidence of widespread RLK shedding events in plants. However, this analysis could not reveal exact cleavage sites that are important for follow up functional studies. Trough RESIST, I seek to develop this new field of ectodomain shedding in plant biology and study the mechanisms of regulation and the consequences of plant RLK shedding. To do so, I aim to establish a platform for experimental identification of shedding events in plants by adapting cutting edge methods recently developed in medical sciences for precise identification of processed membrane proteins and released ectodomains in Nicotiana benthamiana. I will use this platform to analyse the plant sheddome (the repertoire of shed proteins) and its dynamics upon defence activation and to identify interesting shedding events for functional characterization.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
52428 JULICH
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.