Project description
Biological insight into recurrent miscarriage
Recurrent miscarriage is the occurrence of three or more consecutive pregnancy losses and undoubtedly is mentally and physically devastating for couples. Maternal age, uterus abnormalities or immune reactions may be underlying causes. Delineating the complex causes of recurrent miscarriage would help develop novel treatments. To address this medical need, the RMCmplxPheno project funded by the Marie Skłodowska-Curie Actions programme proposes to study electronic health records to identify clinical phenotypes associated with recurrent miscarriage. Machine learning will be applied for the classification of patients, while genetic analyses will provide important insight into the biological mechanisms.
Objective
Recurrent miscarriage (RM) affects 1% of couples trying to conceive and has a wide range of negative physical and mental impacts yet still has few evidence-based, preventative treatments. RM is used as a catch-all term for an event with diverse underlying causes. Broad categorisation hampers research targeting specific causes that could identify potential therapeutic avenues. This generalisation compounds trauma for patients and the path to successful pregnancy is unclear.
As a MSCA fellow at the University of Copenhagen, I will generate deeper understanding of RM aetiology by identifying granular subgroups of RM and elucidating their underlying biology. To do so I will: 1) Establish novel phenotypes derived from clinical data in electronic health records, including ultrasound images, and use these phenotypes to identify clinical phenotypes driving current miscarriage classification systems. 2) Apply hypothesis-free unsupervised machine learning to clinical data to disentangle complex phenotypes of RM into clinically relevant subgroups. 3) Employ genetic analyses to characterise biological pathways underlying these RM subgroups and identify potential therapeutic avenues.
This fellowship will allow me to apply my skills and expertise in large-scale biomedical data analysis and genetics to a new field in which I will pursue a long-term career. In particular it will provide training in field specific scientific knowledge (obstetrics and gynaecology), cutting edge techniques (machine learning) and transferable skills towards scientific leadership (research management).
Taken together the outcomes of this interdisciplinary research will have ramifications for researchers, clinicians and patients. For researchers, a granular understanding of RM and its causes will enable discovery of novel therapeutic avenues. For clinicians, it would assist clinical decision making towards personalised treatments. For patients, alleviation of trauma through empowerment with information.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine gynaecology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
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