Project description
The role of microRNAs in skin allergies
Skin contact with an allergic substance such as metal, medications or cosmetics may lead to itchy rashes. These are caused as part of the body’s immune response by tissue-resident memory T (TRM) cells upon second contact with the allergen. However, the mechanisms that generate and maintain these TRM cells remain elusive. Funded by the Marie Skłodowska-Curie Actions programme, the mirSKIN project will focus on the role of microRNAs on epidermal TRM cells. Researchers will analyse the microRNA and mRNA profile of TRM cells of a mouse model of allergic contact dermatitis and from patients suffering from this same condition. Results will provide a better understanding of the mechanisms underlying skin allergies and pave the way towards more effective treatments.
Objective
Allergic contact dermatitis (ACD) is an inflammatory skin condition that is characterized by dry, scaly, and itchy skin. An important part of the immune response to contact allergens is local memory, which is mediated through specialized cells called resident memory T (TRM) cells. However, the mechanisms involved in the generation and maintenance of the allergen-induced TRM cells in the skin still need to be determined. MicroRNAs (miRNAs) are short RNA molecules that regulate the expression of a large number of genes on a post-transcriptional level. This project aims to clarify what miRNAs are important for the generation and maintenance of epidermal TRM cells in a mouse model of ACD and patients with ACD. In this current project, we plan to use state-of-the-art methods that have been unavailable to me previously, including NanoString and single-cell RNA sequencing to analyze the miRNA and mRNA data together with functional assays to validate the findings from both mice and human data. The current project will expand the knowledge of miRNA expression in ACD and thereby lead to a better understanding of molecular mechanisms and pathways that contribute to the development of ACD leading to possible new treatment strategies. During this project, I will grow as an independent researcher as in my previous projects I focused on keratinocytes in the context of skin inflammation, and to establish a comprehensive understanding of skin diseases it would be essential to learn in deeper detail about the role of T cells in the context of skin. Therefore this project would complement my current education and help me develop my career. Under the guidance of prof Bonefeld, I would develop as an independent researcher and she would be a good female role model to an emerging young scientist.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics RNA transcriptomes
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.