Objective
Plant diseases have been causing global issues to agriculture, economy, and humanity. Understanding how plant disease resistance works is vital to finding durable and sustainable solutions to protect our crops. One key molecular hallmark of plant immune activation is mediated by calcium signalling, which is a commonly shared and well-known second messenger in all cellular organisms. However, it has been overlooked how calcium signalling is activated by plant intracellular nucleotide-binding and leucine-rich repeat immune receptors (NLRs), which are often one of the main genetic resources of plant breeding for disease resistance. In addition, upon activation, it is not known how the immune receptors activate a large scale of defence genes via calcium signalling. To answer these questions, I will be addressing three objectives: 1) Decoding compartmentalized calcium dynamics activated by intracellular immune receptors (NLRs); 2) Characterizing the role of helper NLRs in producing calcium signatures and transcriptional reprogramming; 3) Identifying calmodulins (calcium-binding proteins) that interact with key transcription factors to decode the calcium signature during effector-triggered immunity mediated by NLRs. I will use an interdisciplinary approach combining cell biology, genetics, and multi-omics. The outcome of this study will expand our understanding of plant immunity and provide novel insights for crop breeding specifically tailored to counter hazardous pathogens. I aim to 1) broaden my expertise in plant signalling research; 2) expand my toolbox of cellular biology and genetics; 3) develop the leadership skills required for managing a research group. Furthermore, I will strengthen my scientific track record and network. This DeCaETI project will be performed at the Institute of Biology Leiden, Leiden University. Implementation of the project will support me to run this project successfully and advance my career to become an independent future leader.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- agricultural sciences agriculture, forestry, and fisheries agriculture agronomy plant breeding
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2311 EZ Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.