Project description
A biocompatible implant for cartilage repair
Articular cartilage (AC) is a specialised connective tissue that lines the surfaces of bones in our joints, enabling low-friction, smooth and easy movement. AC has limited regenerative capacity due to the avascular and aneural nature of the tissue, making it prone to degeneration and injury. This may cause pain and impaired mobility and eventually lead to osteoarthritis (OA). Current OA treatments are limited to surgical replacement of the joint with a prosthesis, which has its limitations and is not suitable for younger patients. Funded by the Marie Skłodowska-Curie Actions programme, the RECoil3D project aims to develop a new dynamic load-bearing implant for AC repair that uses a scaffold with extracellular matrix components and biodegradable polymers.
Objective
Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC can cause underlying bone damage creating an osteochondral (OC) defect. OC defects cause pain, impaired mobility and can develop to Osteoarthritis (OA). OA is the most common form of arthritis, affecting nearly 10% of the population worldwide, and a serious disease representing a significant economic burden to patients and society. In Europe, the cost of OA per patient is estimated to exceed € 10,000 per year. At present, the treatment options for OA are limited to surgical replacement of the diseased joint with a prosthesis. While this procedure is well established, it is not without its limitations, and failures are not uncommon. In addition, joint replacement prostheses have a finite lifespan, making them unsuitable for the growing population of younger and more active patients requiring treatment for OA. While significant progress has been made in this field, realising an efficacious therapeutic option for the treatment of unresolved OA remains elusive and is considered to be one of the greatest challenges in the field of orthopaedic regenerative medicine. One of the critical problems when repairing OC defects is the poor repair of the AC due to its repair with a low-quality scarring tissue, lacking the native aligned collagen microarchitecture. Therefore, there is a societal need to develop new strategies for AC regeneration.
The RECoil3D project aims to develop a new generation of dynamic load-bearing implants based on the Reinforcement of an extracellular matrix (ECM)-derived scaffold containing an aligned pore architecture with a dynamic Coil-shaped 3D printed polylactic acid (PLA) constructs for AC tissue repair.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering amorphous solids amorphous semiconductors
- engineering and technology industrial biotechnology biomaterials bioplastics polylactic acid
- medical and health sciences clinical medicine rheumatology
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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28906 Getafe
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.