Objective - To describe better the molecular defects leading to familial Mediterranean fever (FMF).Expected Outcome- The molecular basis of FMF and other forms of arthritis should be understood better, thus providing an opportunity for improved early diagnosis, therapy and prevention.- Identification of a sufficient number of FMF families and preparation of a detailed clinical description of a series of Turkish, Spanish and non-Askhenazi Jewish patients with FMF serving as a basis for an optimal genetic mapping of the molecular defects in FMF;- Genetic and physical mapping of the candidate regions of the FMF gene, first through the exclusion of gene-regions that have a recombinant event in an affected individual, and second, by a continuous mapping of identified candidate regions. The location of the disease gene will then be identified by molecular genetic techniques and through studying linkage disequilibria in each of the ethnic groups. Programme(s) IC-AVICENNE - Avicenne Initiative (Science and technology cooperation with the Maghreb and the countries of the Mediterranean Basin), 1991- Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Sondureta Hospital EU contribution No data Address 07001 Palma de Mallorca Spain See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all TEL AVIV UNIVERSITY Israel EU contribution No data Address Ramat-Aviv 69978 RAMAT - AVIV See on map Total cost No data University of Ankara Türkiye EU contribution No data Address 06220 Ankara See on map Total cost No data
