Objective
All animals have specialized cells that can generate small electric currents, such as neurons or muscle cells. However, the ability to generate external electric fields is restricted to only few teleost and elasmobranch species. This function evolved independently at least six times, generating different specialized electric organs composed of cells called electrocytes that generate these electric fields. In most species, electrocytes have convergently evolved from muscle cells. Nonetheless, in Apteronoidae, a small tropical clade that shares a common ancestor with other fish with a myogenic electric organ, electrocytes have evolved de novo from spinal cord motor neuron precursors. These neurogenic electrocytes create the electric organ by packing axons with unique morphological properties: no pre-synaptic terminal, U-shape with a 5-fold changing diameter and unique myelination pattern. However, nothing is known about the molecular changes that underlie these striking evolutionary novelties, to a large extent due to the difficulty to access the somas of electrocytes, which are intermingled within other spinal cord cells. The goal of ONE is to elucidate the genomic and regulatory bases of the origin of the neurogenic electrocytes in Apteronoidae. This will be possible thanks to the use of cutting-edge single-cell multi-omics technologies, which will allow us to investigate this cell type at the transcriptomic and regulatory levels for the first time (Aim 1). I will then use comparative approaches with close fish relatives and between neurogenic and myogenic electrocytes to identify unique and convergent evolutionary genomic patterns (Aim 2). Altogether, ONE will positively impact neuroscience and evolutionary research, revealing new mechanisms of novel cell-type evolution. Moreover, we will discover new genetic variants that might be applied to biotechnology and biomedicine and that will further help to raise awareness of the importance of conserving Biodiversity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences ecology ecosystems
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08003 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.