Objective
Cardiovascular diseases (CVD) are highly prevalent in Europe, causing more than 3.9 million deaths yearly. Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the main underlying cause of CVD. Available strategies to treat and prevent atherosclerosis remain suboptimal, therefore, better understanding of its regulatory mechanisms is required to design new approaches to treat this inflammatory disease. Recent cardiovascular outcome trials demonstrated that GLP-1R agonists (GLP-1RA) reduce the rates of major cardiovascular events. This GLP-1RA effects are hypothesized to reflect modifications on atherosclerosis, through anti-inflammatory actions. However, the mechanisms linking GLP-1R activation to control of atherosclerosis and vascular inflammation, as well as the cells/tissues mediating these effects, are far from understood. The main aim of my proposal is to identify the mechanism by which GLP-1RA regulate atherosclerosis regression, offering a unique and innovative opportunity to study the role of yet unexplored GLP-1R+ cell types (vascular smooth muscle cells, and neurons of the enteric and central nervous system) mediating its effects. The multidisciplinary perspective adopted, combining my background in academic research with preclinical models, the experience in biomedical research of the host supervisor, and the clinic/translational perspective of the partner supervisor, gives this AtheroGLP1 project with the strong potential to identify novel mechanisms that are expected to have immediate translational importance for targeted use of GLP-1RAs in the clinic to treat atherosclerosis and CVD. Importantly, this proposal will allow me to gain transferable competences and get trained in the latest in vivo and molecular techniques to assess vascular and systemic inflammation, letting me to reach scientific maturity to stablish a similar facility at the host institution, promoting my transition to become an independent researcher in the ERA.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15782 Santiago De Compostela
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.