Project description
How brown adipose tissue can help combat obesity
In the last 50 years, obesity and cardiometabolic disease rates have surged, with a chilling prediction of over 1 billion obese individuals worldwide by 2030. Among the potential solutions, brown adipose tissue (BAT) has emerged as a promising target due to its ability to dissipate energy as heat. However, little is known about how diet interacts with BAT function, hindering the development of effective weight loss strategies. With the support of the Marie Skłodowska-Curie Actions programme, the FoodBAT project will investigate the effects of food intake on BAT function. Researchers aim to understand how gut hormones stimulate diet-induced thermogenesis and BAT oxidative metabolism. This understanding will be crucial in devising novel pharmacological and lifestyle-related interventions to combat obesity.
Objective
The last five decades have been characterized by an increase in obesity and cardiometabolic diseases. Recent predictions indicate that more than 1 billion people will be obese by 2030 worldwide. Contrary to white adipose tissue, brown adipose tissue (BAT) dissipates energy as heat and has been considered an important target for treating obesity and cardiometabolic diseases. Nevertheless, little is known about the interaction between diet, of the most important modifiable risk factors for cardiometabolic diseases, with BAT function. To develop new weight-loss strategies, it is essential to understand how food intake modulates BAT function by interacting with endocrine factors and how this interaction affects diet-induced thermogenesis in lean individuals and those with obesity.
Recent data indicate that DIT is associated with BAT function and that gut hormones play an important part in the activation of BAT during the postprandial phase. Yet, the mechanism remains to be elucidated. Moreover, it is unclear whether DIT and cold-induced thermogenesis (CIT) share similar metabolic pathways and how the manipulation of food intake can affect BAT and, thus, energy expenditure.
The main aims of FoodBAT are to investigate how the acute intake of a mixed meal modulates gut hormones to stimulate diet-induced thermogenesis (DIT) and BAT oxidative metabolism and to understand how this interplay differs between lean and obese individuals. Also, we will investigate how a cold acclimation protocol affects this interaction to modulate DIT in individuals with obesity. Finally, FoodBAT will unravel the connections and differences between DIT and CIT by comparing the gene expression and mitochondrial respiration of brown adipocytes stimulated with either nutrient overload, isoproterenol, or a combination of both. These findings will be pivotal for the development of new pharmacological and non-pharmacological (lifestyle-related) strategies to combat obesity.
Fields of science (EuroSciVoc)
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2022-PF-01
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20014 Turku
Finland
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