Objective
Breast Cancer is the most commonly diagnosed cancer in Europe and remains the first cause of cancer death in women (nearly 92,000 deaths in 2020). Precision medicine uses data-driven insights to reflect the heterogeneity of patients and improve cancer care by offering actionable oncology treatment options. Tumour tissue heterogeneity is the leading cause for inter-patient variation in treatment response. One of the largest sources of tissue heterogeneity arises from post-translational glycosylation of proteins and aberrant glycosylation is a hallmark of breast and other cancers. Yet, substantial gaps remain in our knowledge of cancer glycans. Glycomics (the comprehensive study of the glycome) offers the potential to provide the global glycosylation status (GlycoMap) of a patient and shed new light on tumour heterogeneity to guide precision medicine. This project aims to address the substantial knowledge gap in breast cancer tumour glycosylation data by developing an integrated glycomics workflow to produce patient-specific 'GlycoMaps'. By including glycosaminoglycan (GAG) 'omics from intact GAGs for the first time, combined with other glycan analyses will enable the generation of Breast Cancer GlycoMaps from resistant and drug-sensitive patient-derived organoids (mini avatars of tumour tissue), defining residual tumour tissue following treatment that causes relapse and metastasis. The mission and design of the GlycoMap project is to train the researcher, who has a background in GAGomics, proteoglycan biology and bioinformatics, with expanded skills and expertise in N-/O-glycomics, organoid culture, hi-resolution 3D imaging and advanced bioinformatics in the context of breast cancer, augmenting her future career opportunities, as well as establishing unbiased top-down integrated glycomics to support breast cancer analyses, diagnostics and the development of novel treatments.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
0167 Oslo
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.