Project description
Innovative anti-cancer compounds’ effects on cancers
The ‘eRaDicate’ international programme will empower 10 young scientists in cancer research, with a focus on therapies for stem cell-driven relapse and metastasis. Key targets include nuclear receptors such as the retinoic acid receptor (RAR) and the vitamin D receptor (VDR). Supported by the Marie Skłodowska-Curie Actions programme, the eRaDicate project will evaluate compounds that target RAR and VDR for their anti-cancer effects. The project will develop a dual-action hybrid compound that acts as an antagonist of RARγ and an agonist of VDR, along with pre-formulation strategies. This research will investigate the impact of these compounds on stemness and metastasis in leukaemia, breast, prostate, colorectal, and ovarian cancers, and assess the effectiveness of the pan-RAR antagonist in combating chemotherapy-induced neutropenia.
Objective
The aim of the “eRaDicate” international, multidisciplinary, and intersectoral cancer drug research and development programme is to empower 10 young scientists to become specialists in cancer research and drug development, while developing new therapies against cancer stem cell-driven relapse and metastasis. Nuclear receptors, such as retinoic acid receptor (RAR) and vitamin D receptor (VDR), play key roles in many hallmarks of cancer and constitute effective targets for modern cancer therapy.
To address the EU priority “Mission Cancer”, we will 1) test the anti-cancer activity of RAR and VDR targeting compounds; 2) design and synthesise a highly innovative dual action hybrid compound acting simultaneously as RARγ antagonist and VDR agonist; 3) devise pre-formulation strategies for our compounds; 4) and develop a novel, deep learning-based cancer analysis and diagnostics method.
We will test how our RAR and VDR-targeting compounds affect stemness and metastatic potential in leukaemia, breast, prostate, colorectal, and ovarian cancer. In parallel, we will assess if the pan-RAR antagonist is effective against chemotherapy-induced neutropenia. For the development of the RAR and VDR targeting compounds into administrable medicines, ready for eventual commercialisation, we will develop pre-formulation strategies. We will generate a novel and highly innovative label-free image analysis method based on histoplasmonic cytometry. The project will have lasting scientific, economic, and societal impact.
In order to be prepared for a wide spectrum of career opportunities, we will train the doctoral candidates (DCs) not only to perform original and independent research on an internationally competitive level, but also endow them with creative, critical and entrepreneurial mindset, coupled with persistence in following their objectives.
Our consortium consists of 8 academic and 1 industrial beneficiary, as well as 12 associated partners to provide training and secondments.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1090 Wien
Austria
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Participants (7)
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50137 Wroclaw
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84105 Beer Sheva
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15782 Santiago De Compostela
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1020 Wien
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00-927 Warszawa
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02 091 Warszawa
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D02 CX56 Dublin
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Partners (15)
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1030 Wien
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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Cork
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3500 Krems an der Donau
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3086 La Trobe University
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17489 Greifswald
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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61-614 Poznań
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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4001 Brisbane
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30-348 Krakow
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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91031 Jerusalem
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Participation ended
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M5S 1A1 Toronto
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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36078 Valdagno
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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B15 2TT Birmingham
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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3500 KREMS-STEIN
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5961 NM HORST
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