Project description
Training in genetic mutations affecting inborn immunity
The human immune system is crucial for fighting infections and removing abnormal cells. Inborn errors of immunity (IEI) are rare genetic mutations that affect immune function, with over 400 conditions that have a prevalence similar to leukaemia. These mutations lead to a range of symptoms and varying treatment responses. With the support of the Marie Skłodowska-Curie Actions programme, the IMMERGE project will bring together leaders from clinical, basic research, and biotech fields to train doctoral candidates. It will evaluate the impact of IEI on various immune cell types using single-cell and bulk multi-omics approaches. The project will develop computational tools to analyse altered cellular pathways associated with IEIs and create pre-clinical models for genetic correction or simulation.
Objective
The human immune system controls the efficiency to respond to infections and eliminate aberrant cells, such as cancer cells. Immune function depends on the balanced contribution of many genes, encoding for receptors, cytokines, cell signalling molecules and transcription factors and are modulated by a wide range of environmental and epigenetic factors. Monogenic mutations for immune-related genes, also known as Inborn Errors of Immunity (IEI), provide unique examples for understanding immune fitness. IEI, individually considered as rare diseases, constitute a group of >400 immune disorders with a combined prevalence similar to leukemias (1/1,000-1/5,000). For a given mutated gene, IEI patients can display a wide range of phenotypic expressivity (from asymptomatic to severely impaired) and different responses to treatments. Therefore, there is an unmet need to address the wide underlying impact of IEI. Previous EU consortia have not addressed these questions in full. It is therefore needed a new generation of researchers, equipped with a complete set of scientific, technological and strategic skills; and a wide vision to face the outstanding challenges in the IEI field. To this end, the IMMERGE MSCA DN combines the talent of leaders from different clinical and basic research and biotech environments to train 11 doctoral candidates. Through our research activity and training activities, we will address key challenges in the field: 1) To assess the functional impact of IEI in different immune cell types through single cell and bulk multiomics. 2) To develop computational tools for dissecting the altered cellular pathways underlying specific IEI. 3) To genetically correct or model IEI and develop pre-clinical models. With our strategy, IMMERGE will generate an outstanding network of professionals able to develop impactful studies that will change the field, generate tools for personalised medicine and generate awareness in the society and influence policy makers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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08916 Badalona
Spain
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Participants (8)
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75794 Paris
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79106 Freiburg
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20132 Milano
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69117 Heidelberg
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91120 Jerusalem
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08950 ESPLUGUES DEL LLOBREGAT
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20122 MILANO
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38122 Trento
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Partners (20)
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6500 Bellinzona
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08007 Barcelona
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CB2 1TN CAMBRIDGE
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79098 Freiburg
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20132 Milano
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91904 Jerusalem
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08002 Barcelona
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38122 Trento
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6900 Lugano
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08021 Barcelona
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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82152 Planegg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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28039 MADRID
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
753 30 UPPSALA
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74909 Baden-Baden
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83530 Schnaitsee
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91120 Jerusalem
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CB10 1SA SAFFRON WALDEN
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13284 Marseille
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4051 Basel
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20122 MILANO
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