Objective
Achromobacter species are rapidly emerging Gram-negative opportunistic bacteria intrinsically resistant to several antibiotics and are often the cause of healthcare-associated infections, especially in individuals with compromised immune systems or underlying conditions. Following years of misclassification of Achromobacter spp. isolates combined with complicated species typing, the understanding of the ecology of Achromobacter spp. and their clinical significance is lacking. GEM-SEE-Achro aims to answer the questions regarding the population structure, evolution, adaptation, antibiotic resistance development, and genetic variability of Achromobacter spp. both globally and locally, providing crucial insights into the factors contributing to their prevalence, antimicrobial resistance patterns and potential novel therapy approaches. Analysis of whole genome sequencing (WGS) data allows to disentangle these questions. Therefore, I propose the largest Achromobacter spp. study to date including over 800 WGS encompassing its global diversity sampled from both the environment and infected patients. Employment of a number of bioinformatics analysis methods—gene content difference analysis; single nucleotide variant and mobile genomic element identification and association with population structure; evolutionary and migration rates analysis using Bayesian phylogenetics; and resistance phenotype association with genomic differences—will help to answer the fundamental questions of how these bacteria evolve and adapt to their environment, what are the main differences in genetic composition between the environmental and clinical samples, and how these differences can inform us about the population structure and antibiotic resistance development in Achromobacter spp. The gained knowledge could be generalised and applied to studies of other less studied bacterial pathogens.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences genetics nucleotides
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
01513 Vilnius
Lithuania
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.