Project description
Uncovering obesity mechanisms through bioavailable compounds from apple pomace
Obesity escalates the risk of cardiometabolic diseases. Within the EU, 53 % of adults are overweight. Embracing a healthier lifestyle and dietary habits, such as increasing fibre intake and consuming bioactive compounds, can aid in preventing these diseases. The MSCA-funded DAMA-BIOX project utilises apple pomace (AP) to extract encapsulated phenolic compounds (APF) and fibres, aiming to elucidate the mechanisms of the bioavailable fraction’s antioxidant and anti-inflammatory properties in cells exposed to palmitic acid, mimicking obesity conditions. The project employs an innovative and humanised three-dimensional co-culture intestinal barrier model to replicate human intestinal absorption. By using and recycling AP, the project targets sustainable food production thereby contributing to environmental sustainability, promoting circularity, and enhancing public health.
Objective
Overweight and obesity are risk factors for cardiometabolic diseases that can be partially prevented by adopting healthier lifestyles and eating habits, such as increased fibre intake and other bioactive compounds, such as phenolics. However, in the European Union, the proportion of overweight adults varies from 37 to 73%, averaging 53%. DAMA-BIOX uses apple pomace (AP) to recover, purify and encapsulate phenolic compounds (APF) and fibres to unveil the mechanisms of antioxidant and anti-inflammatory properties of the bioavailable fraction in 3T3-L1 adipocytes challenged with supraphysiological concentrations of palmitic acid to simulate obesity. DAMA-BIOX implements the use of an innovative humanised three-dimensional co-culture intestinal barrier model consisting of human enterocytes (Caco-2) and human fibroblasts (CCD-18Co) to recapitulate human intestinal absorption. The use and reuse of AP also target sustainable food production by harnessing agro-industrial side streams, representing a tangible solution to produce functional foods. DAMA-BIOX addresses this aim across four work packages, contributing to the environment, agroindustry’s circularity, and public health. DAMA-BIOX brings together cross-sectoral expertise, strengthens the European capacity for healthier and sustainable innovations, and generates new possibilities for food export. The prestigious fellowship will provide the experienced researcher (PF) with the first step in a new research field that will act as a platform to kick-start the future international academic career. The University of Limerick is the place of renowned subject experts, and exposure to international collaborators will provide the PF with a unique opportunity to grow as an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology other engineering and technologies food technology
- agricultural sciences animal and dairy science dairy
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
- Limerick
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.