Project description
Transmembrane anion transporters leveraging light-activated rotating molecular motors
Transmembrane transport of anions (negatively charged ions and molecules) is essential to cell function and responsible for processes including pH regulation, maintenance of cell volume and chemical signalling. Mimicking this is important to synthetic biology and biotechnological applications, yet most synthetic transmembrane anion transporters are not well controlled. With the support of the Marie Skłodowska-Curie Actions programme, the MOTOTRANS project aims to develop transmembrane anion transport systems activated by light-driven molecular motors. The team will characterise the out-of-equilibrium dynamics of the rotating molecular motors and their influence on membrane, carrier or channel properties in an effort to enhance transport activity.
Objective
"Anion transport through membranes, mediated by transport proteins, is one of the most important processes in living cells. Recently, a number of synthetic transmembrane anion transporters have been developed. However, unlike proteins, they usually do not display responsive behaviour, making their function unspecific. There are only a few methods known for controlling the transport function of these receptors by physiochemical stimuli, with using light being one of the most well-known. These stimuli-responsive receptors, however, only alternate between distinct ""on"" and ""off"" states, while biomolecular systems are able to use the motion of motor proteins to regulate the passage of ions. Two first studies have shown that rotating molecular motors can enhance cation transport through membrane-spanning channels, possibly by influencing conformational dynamics. However, there have been no detailed studies that take advantage of subtle changes in membrane characteristics. It would be very promising to enhance and regulate anion transport across the membrane by integrating molecular machine-like entities into lipid bilayers and synthetic transport systems. MOTOTRANS is a multidisciplinary project that aims to develop transmembrane anion transport systems containing light-driven molecular motors. The out-of-equilibrium rotational dynamics of light-driven molecular motors could influence either membrane, carrier or channel properties, resulting in enhanced transport activity, which will be investigated in work packages 1-3, respectively. The project will have three major impacts: an innovative approach with profound implications in molecular machines and transmembrane anion transport; a significant impact on the fellow's academic career, acquiring new research skills, complementary skills, and scientific connections, enabling access to an academic position in Europe; and the host group and institution will benefit from the fellow's diverse scientific background and network."
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2311 EZ Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.