Project description
Advancing enantioselective synthesis for drug discovery
In drug discovery, enantioenriched molecules are crucial, as even slight differences between enantiomers can lead to vastly different biological effects. However, obtaining these molecules can be challenging. Traditional approaches often rely on aromatic rings, which are two-dimensional and can limit chemical diversity. To overcome this, the medicinal chemistry field is turning to saturated scaffolds, offering greater three-dimensionality and access to novel chemical spaces. Supported by the Marie Skłodowska-Curie Actions programme, the EnantioBioIso project aims to revolutionise this area by developing new enantioselective strategies for synthesising phenyl bioisosteres. These strategies will unlock the potential of polycyclic bridged skeletons, offering exciting new pathways for drug discovery and advancing medicinal chemistry.
Objective
The obtainment of enantioenriched molecules is of fundamental importance since two enantiomers of the same drug candidate can display completely different biological properties. In recent years, an increasing interest in employing saturated scaffolds has been observed in medicinal chemistry since they provide tridimensionality and well-defined exit vectors that give access to novel unexplored chemical space, leading to a higher success in drug discovery programs. Among them, some polycyclic bridged skeletons have been identified as suitable saturated bioisosteres of aromatic rings which represent the common two-dimensional, flat moieties that are routinely employed in the drug discovery process. The aim of EnantioBioIso is to provide novel enantioselective strategies for the synthesis of phenyl bioisosteres, enabling unprecedented approaches to obtain bridged skeletons that are of fundamental importance for medicinal chemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28049 Madrid
Spain
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