Project description
Novel tools for assessing osteosarcopenia
Osteosarcopenia refers to the simultaneous presence of bone loss and decreased bone density alongside loss of muscle mass and strength. Osteosarcopenia is considered a serious health issue because it can lead to increased risk of fractures, falls, disability, and overall reduced quality of life in older adults. Funded by the Marie Skłodowska-Curie Actions programme, the MEASURING project aims to advance MRI technology for osteosarcopenia assessment, addressing the lack of available therapies. Objectives include developing clinically feasible protocols for mapping muscle and bone quality, as well as exploring biomarker associations in postmenopausal women.
Objective
Osteosarcopenia (OSP) is a recently recognized pathology of aging defined as the co-occurrence of osteopenia/osteoporosis (OP) and
sarcopenia (SP) leading to high morbidity, disability, and mortality with an associated tremendous economic burden. There are no
approved therapies specifically targeting OSP. It is critical to monitor OSP pathophysiology, progression, and response to therapy
holistically by simultaneously measuring effective quantitative biomarkers sensitive to early changes in tissues to provide meaningful
information on various mechanisms involved in OSP.
As an MSCA fellow, Dr. Barbieri will exploit crucial training at i) the University of Bologna (Host Institution), ii) Rizzoli Orthopedic Institute (Associated Partment linked to the beneficiary), and Stanford University (Associated Partner) during a secondment of 8 months. The excellent network of mentors and participant organizations will ensure the success of the overarching overall objective of the project:
to propose technical advancements in Magnetic Resonance Imaging (MRI) sequences, protocols, and processing to overcome the
current limitations of MRI-based assessment of cortical and trabecular porosities and to use a multi-parametric approach to study
association of bone and muscle quality biomarkers in postmenopausal osteoporotic and osteosarcopenic women. The specifics
objectives are (1) to develop a rapid MRI sequence to measure cortical and trabecular porosities, which is not currently feasible, (2) to
develop a clinically feasible MRI protocol to map muscle and bone quality, and (3) to assess the association between bone biomarkers
and muscle quality biomarkers in OP and OSP women.
The excellent technical expertise, paired with training in clinical imaging, will allow Dr. Barbieri to produce: a new MRI sequence to be
deployed open access; a new multi-parametric approach to study OSP; information on bone and muscle biomarkers association; and
dissemination to crucial target audiences.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
40126 Bologna
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.