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Multiparametric Evaluation of osteosarcopeniA diSease Using magnetic Resonance ImagiNG

Projektbeschreibung

Neue Analysemethoden für Osteosarkopenie

Osteosarkopenie bezeichnet das gemeinsame Auftreten von Knochenschwund und verminderter Knochendichte, begleitet durch Muskelschwund und Kraftverlust. Osteosarkopenie ist ein ernstes Gesundheitsproblem, da das Risiko für Knochenbrüche, Stürze, Behinderung und insgesamt geringere Lebensqualität bei älteren Menschen steigen kann. Finanziert über die Marie-Skłodowska-Curie-Maßnahmen wird im Projekt MEASURING die MRT-Technologie für die Bewertung von Osteosarkopenie verbessert, um den Mangel an Behandlungen zu beheben. Zu den Zielen gehört, klinisch praktikable Protokolle zur Dokumentation der Muskel- und Knochenqualität aufzustellen und mögliche Biomarker bei Frauen nach der Menopause zu bestimmen.

Ziel

Osteosarcopenia (OSP) is a recently recognized pathology of aging defined as the co-occurrence of osteopenia/osteoporosis (OP) and
sarcopenia (SP) leading to high morbidity, disability, and mortality with an associated tremendous economic burden. There are no
approved therapies specifically targeting OSP. It is critical to monitor OSP pathophysiology, progression, and response to therapy
holistically by simultaneously measuring effective quantitative biomarkers sensitive to early changes in tissues to provide meaningful
information on various mechanisms involved in OSP.

As an MSCA fellow, Dr. Barbieri will exploit crucial training at i) the University of Bologna (Host Institution), ii) Rizzoli Orthopedic Institute (Associated Partment linked to the beneficiary), and Stanford University (Associated Partner) during a secondment of 8 months. The excellent network of mentors and participant organizations will ensure the success of the overarching overall objective of the project:
to propose technical advancements in Magnetic Resonance Imaging (MRI) sequences, protocols, and processing to overcome the
current limitations of MRI-based assessment of cortical and trabecular porosities and to use a multi-parametric approach to study
association of bone and muscle quality biomarkers in postmenopausal osteoporotic and osteosarcopenic women. The specifics
objectives are (1) to develop a rapid MRI sequence to measure cortical and trabecular porosities, which is not currently feasible, (2) to
develop a clinically feasible MRI protocol to map muscle and bone quality, and (3) to assess the association between bone biomarkers
and muscle quality biomarkers in OP and OSP women.

The excellent technical expertise, paired with training in clinical imaging, will allow Dr. Barbieri to produce: a new MRI sequence to be
deployed open access; a new multi-parametric approach to study OSP; information on bone and muscle biomarkers association; and
dissemination to crucial target audiences.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Finanzierungsplan

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

Alle im Rahmen dieses Finanzierungsinstruments finanzierten Projekte anzeigen

Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) HORIZON-MSCA-2023-PF-01

Alle im Rahmen dieser Aufforderung zur Einreichung von Vorschlägen finanzierten Projekte anzeigen

Koordinator

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Netto-EU-Beitrag
€ 172 750,08
Adresse
VIA ZAMBONI 33
40126 Bologna
Italien
Region
Nord-Est Emilia-Romagna Bologna
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
Keine Daten

Partner (2)