Project description
The effects of early life infections on non-communicable diseases in children
Infections during the early stages of life can have long-term effects on organ systems, potentially leading to non-communicable diseases (NCDs). Supported by the Marie Skłodowska-Curie Actions (MSCA) programme, the ELIaD project investigates how early-life infections impact the development of NCDs in children. Specifically, the project will integrate existing data on infections with information on NCDs and their intermediate phenotypes across Europe. Using data from the EU Child Cohort Network, the project will analyse health outcomes and establish standardised variables related to infections. It will identify vulnerable groups and compile a comprehensive open dataset on infections and NCDs in children. This dataset is expected to inform the development of public health policies designed to prevent and control NCDs.
Objective
"A number of associations confirm that a broad spectrum of non-communicable diseases (NCDs) can stem from infections, but evidence remains limited. Of particular interest are infections that occur during vulnerable early life stages, as they hold the potential to trigger developmental adaptations of various organ systems with life-long consequences. The ""Early Life Infections and NCDs"" (ELIaD) project aims to elucidate the role of early life infections on NCDs development by bridging existing data on infections with information on NCDs and their intermediate phenotypes in children across Europe. Leveraging the extensive resources of the EU Child Cohort Network, ELIaD will use existing harmonized prospective data on neurodevelopmental, cardiometabolic, and respiratory health outcomes linked to major NCDs. Simultaneously, the project will pioneer with the development of harmonised variables on infections in the child-cohorts that is currently lacking. Detailed prospective information on sociodemographic, lifestyle and environmental characteristics will be integrated to assess confounding, mediation and effect modification of the associations. Analyses will particularly take into account specific age windows of susceptibility. The project will create and disseminate new knowledge on links between early life infections and NCDs in children and will identify vulnerable groups. A key output of ELIaD will be the creation of a large open dataset on infections and NCDs in children, which will allow further investigation of causal links (e.g. with gastrointestinal diseases), in-depth investigations into the underlying mechanisms and the extension of evidence into adulthood. The outcomes of this research will play a vital role in shaping public health policies geared towards the prevention and control of NCDs. The project combines researcher's skills with those of the supervisor and his team at the host institute facilitating cross-disciplinary knowledge exchange and training."
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.