Descrizione del progetto
Gli effetti delle infezioni nelle prime fasi della vita sulle malattie non trasmissibili nei bambini
Le infezioni nelle prime fasi della vita possono avere effetti a lungo termine sui sistemi degli organi, portando potenzialmente a malattie non trasmissibili. Il progetto ELIaD, finanziato dal programma di azioni Marie Skłodowska-Curie, studia l’impatto delle infezioni nelle prime fasi della vita sullo sviluppo delle malattie non trasmissibili nei bambini. In particolare, il progetto integrerà i dati esistenti sulle infezioni con informazioni sulle malattie non trasmissibili e sui loro fenotipi intermedi in tutta Europa. Utilizzando i dati della rete di coorti infantili dell’UE, il progetto analizzerà i risultati sanitari e stabilirà variabili standardizzate relative alle infezioni. Identificherà i gruppi vulnerabili e compilerà un set di dati aperti completo sulle infezioni e le malattie non trasmissibili nei bambini. Questo set di dati dovrebbe informare lo sviluppo di politiche di salute pubblica volte a prevenire e controllare le malattie non trasmissibili.
Obiettivo
"A number of associations confirm that a broad spectrum of non-communicable diseases (NCDs) can stem from infections, but evidence remains limited. Of particular interest are infections that occur during vulnerable early life stages, as they hold the potential to trigger developmental adaptations of various organ systems with life-long consequences. The ""Early Life Infections and NCDs"" (ELIaD) project aims to elucidate the role of early life infections on NCDs development by bridging existing data on infections with information on NCDs and their intermediate phenotypes in children across Europe. Leveraging the extensive resources of the EU Child Cohort Network, ELIaD will use existing harmonized prospective data on neurodevelopmental, cardiometabolic, and respiratory health outcomes linked to major NCDs. Simultaneously, the project will pioneer with the development of harmonised variables on infections in the child-cohorts that is currently lacking. Detailed prospective information on sociodemographic, lifestyle and environmental characteristics will be integrated to assess confounding, mediation and effect modification of the associations. Analyses will particularly take into account specific age windows of susceptibility. The project will create and disseminate new knowledge on links between early life infections and NCDs in children and will identify vulnerable groups. A key output of ELIaD will be the creation of a large open dataset on infections and NCDs in children, which will allow further investigation of causal links (e.g. with gastrointestinal diseases), in-depth investigations into the underlying mechanisms and the extension of evidence into adulthood. The outcomes of this research will play a vital role in shaping public health policies geared towards the prevention and control of NCDs. The project combines researcher's skills with those of the supervisor and his team at the host institute facilitating cross-disciplinary knowledge exchange and training."
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Invito a presentare proposte
(si apre in una nuova finestra) HORIZON-MSCA-2023-PF-01
Vedi altri progetti per questo bandoMeccanismo di finanziamento
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinatore
3015 GD Rotterdam
Paesi Bassi