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Chirality detection: nanoparticles for optimised plasmonic enhancement of circular dichroism (NanOptCD)

Project description

Improving the sensitivity of chirality detection

Circular dichroism (CD) spectroscopy is used to characterise the macromolecular structure of chiral (asymmetric) molecules based on the different absorbance of left and right circularly polarised light. Optically active chiral molecules preferentially absorb one or the other. It is widely used to characterise large molecules such as proteins and DNA. However, many molecules produce weak CD signals below the measurable limit. Plasmonic nanoparticles are extremely strong absorbers and transmitters of light and their interactions with other molecules could amplify their CD signals. With funding from the Marie Skłodowska-Curie Actions programme, the NanOptCD project aims to support their use via theoretical characterisation of plasmonic CD enhancement, analytical tools, and customised nanoparticles.

Objective

NanOptCD aims to facilitate the sensitive use of plasmonic enhanced circular dichroism (CD) spectroscopy in research & development (R&D). Many molecules possess weak CD signals below the measurable limit. Interactions of molecules with plasmonic nanoparticles are very promising for generating strongly enhanced CD signals. Nevertheless, this enhancement mechanism needs further theoretical characterisation in order to facilitate mature applications in R&D. NanOptCD will offer this by analysing the fundamental dependencies of plasmonic CD enhancement with ab initio calculations. Furthermore, NanOptCD will deliver tools for the analysis of plasmonic enhanced CD spectra and customised nanoparticles for optimal plasmonic enhanced CD spectra.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2023-PF-01

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Coordinator

AALTO KORKEAKOULUSAATIO SR
Net EU contribution
€ 215 534,40
Address
OTAKAARI 1
02150 Espoo
Finland
Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
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Total cost
No data

Partners (4)