Project description
Exosome biomarkers to advance breast cancer diagnosis
Breast cancer, particularly the triple-negative subtype (TNBC), poses a significant challenge in modern healthcare due to its aggressive nature and lack of well-defined molecular targets, limiting treatment options. Early diagnosis and effective management of TNBC are critical yet difficult to achieve. Exosomes, tiny vesicles found abundantly in biological fluids, show promise as diagnostic markers but are underutilised due to the absence of cost-effective isolation methods. Supported by the Marie Skłodowska-Curie Actions programme, the ExoDiagAI project will develop a microfluidic device that integrates nano-lateral displacement arrays with a Raman biochip to identify TNBC-specific exosome biomarkers. It aims to enhance early breast cancer diagnosis, aligning with the EU’s strategy for advanced diagnostics.
Objective
The ExoDiagAI project is at the forefront of addressing a critical challenge in modern healthcare—early diagnosis and effective management of breast cancer, particularly the aggressive and elusive triple-negative breast cancer (TNBC) subtype. TNBC lacks well-defined molecular targets, hindering treatment options. Exosomes, a subset of extracellular vesicles with unique functions, hold great promise as diagnostic and prognostic markers for various diseases, including cancer. These tiny vesicles are abundant in biological fluids but have been underutilized due to the absence of a cost-effective isolation protocol. Our primary goal is to develop a microfluidic device, integrating nano-lateral displacement arrays with a Raman biochip, to identify exosome biomarkers specific to TNBC and translate this knowledge into clinical practice. This project's main objectives encompass creating the microfluidic device, assessing its surface-enhanced Raman spectroscopy (SERS) capabilities, conducting Raman fingerprinting of exosomes from in vitro cell cultures and patient samples, and employing chemometric analysis to discriminate biomarkers. The distinctive Raman fingerprinting associated with exosomes serves as a promising prognostic and diagnostic marker. By introducing 3D printing SERS technology, we aim to enable real-time monitoring, shedding light on exosome structural integrity. This interdisciplinary project combines organic, inorganic, nano, computational, spectroscopic, and molecular biology techniques, culminating in innovative device fabrication. Ultimately, the ExoDiagAI project holds the potential to revolutionize early breast cancer diagnosis through exosomal biomarkers, aligning with the EU's sustainable development strategy for advanced diagnostic platforms and fostering the career of a promising researcher. This endeavor marks a pivotal step towards enhancing the detection and management of TNBC, addressing a pressing healthcare need.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
07745 Jena
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.