Project description
Improving prostate cancer management with AI
Prostate cancer is a relatively common type of cancer, affecting millions of men worldwide each year. Early-stage prostate cancer, which is often slow-growing, typically has a favourable prognosis with high survival rates, especially when detected and treated promptly. However, advanced or metastatic prostate cancer is more difficult to treat and presents with poorer prognosis. With the support of the Marie Skłodowska-Curie Actions programme, the PROMOTE project aims to train doctoral candidates in the use of omics technologies and artificial intelligence (AI) to improve clinical management of prostate cancer patients. The project will develop non-invasive tools using biomarkers and AI to guide treatment decisions and create effective therapies for advanced disease.
Objective
PROMOTE focuses on multidisciplinary education of doctoral candidates (DCs) in -omics and artificial intelligence (AI) mediated intervention to improve clinical management of Prostate Cancer (PCa). PCa is the second most common malignancy, affecting ~1.3 million men every year worldwide. Tragically, there is a treatment paradox, as ~45% of PCa patients experience slow-growing cancer and are unlikely to progress rapidly, while PCa is not curable at advanced stage. Evidently, clinical management of PCa is not optimal, as patients which do not require treatment are over-treated, while for those that immediate actions are required, efficient treatment are still needed.
To fill the above gaps, PROMOTE was formed to educate DCs in emerging -omics and AI technologies and deliver:
a) novel non-invasive tools (based on biomarker- and AI- models) to guide intervention, and
b) more efficient treatment options for advanced PCa (particularly metastatic) driven by molecular characterisation of the disease phenotypes.
PROMOTE brings together 13 leading centers from different disciplines, including 3 SMEs, 4 university hospitals with clinical laboratories and 2 research institutes and 4 universities, closely collaborating with solid scientific background, as demonstrated by multiple publications. PROMOTE research builds on:
i) available biobanks and -omics datasets within PROMOTE consortium, including >3000 urinary proteomics, >1100 imaging datasets paired with biopsy and pathology data, >350 paired RNA and proteomics urinary profiles, >100 tissue proteomics and ~300 phospho, proteo-genomic and transcriptomics profiles from public repositories,
ii) established software and analytical protocols on -omics data integration, AI feature extraction and integration, systems biology, pathway enrichment, drug repurposing and in vitro testing, and
iii) infrastructure to support hosting and training of DCs.
Moreover, PROMOTE training programme has strong innovation and industrial focus.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN-ID - HORIZON TMA MSCA Doctoral Networks - Industrial Doctorates
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
30659 Hannover
Germany
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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