Objective Bovine Viral Diarrhoea (BVD) is a cosmopolitan disease caused by a pestivirus responsible for various pathological disorders such as digestive, respiratory and genital syndromes and of a debilitating subclinical chronic form. Its main characteristic is a conspicuous immunodepressive action in the host. Recent findings in our laboratory indicate that: - in man there is a prevalence of specific antibodies against BVD virus, particularly to the non-cytopathic (NCP) strains - the contact with susceptible animals is probably an important epidemiological factor - transmission to man seems to be a world-wide phenomenon - antibody specificity is confirmed by Western Blotting Test (WBT) - the screening in AIDS patient groups showed slight higher prevalence for BVDv - in a first screening of 60 samples, a NCP strain was isolated in 2 buffy coats and recognized by specific anti-BVD sera The purpose of the proposed research is: - the further optimization of WBT for BVD virus as reference test for serology in man - screening on human sera in Europe and Zambia with IIF and confirmation with WBT - isolation of Bvdv in human buffy coat samples - characterization of virus isolates - evaluation of an eventual etiopathogenic role on diarrhoea, especially in neonates, and genital disorders in man - comparative study of double infected patients and patients with only HIV infection in order to evaluate the possible interaction of BVD infection with the evolution of HIV infection. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV Programme(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS EU contribution No data Address 122,Av de las Ciencias, s/n apdo. 122 15780 SANTIAGO DE COMPOSTELA Spain See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all Centre National de la Recherche Scientifique (CNRS) France EU contribution No data Address 43 boulevard du 11 Novembre 1918 69622 Villeurbanne See on map Total cost No data Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM) France EU contribution No data Address 213 rue Lafayette 75480 Paris See on map Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution No data Address 42,Kardinaal Mercierlaan 92 3001 HEVERLEE See on map Total cost No data Universidad de Los Andes Venezuela EU contribution No data Address Apart. 30.I.postal La Hechicera Mérida See on map Total cost No data
