Project description
Doctoral training in signalling and metabolism of hub molecules
Metabolic disorders put a significant burden on European healthcare systems and contribute to diseases such as neurodegeneration and cancer. These diseases are often accompanied or even caused by changes in the hub molecules of life (HubMOLs). HubMOLs (such as nicotinamide adenine dinucleotide and coenzyme A) are small molecules with dual functionality that play critical roles in metabolism but also in signalling and gene regulation, for example through their involvement in post-translational protein modifications. Supported by the Marie Skłodowska-Curie Actions programme, the HubMOL project will train 16 doctoral candidates in experimental, computational, and clinical methods to explore hub molecule biology and develop personalised vitamin supplementation strategies. Furthermore, the project aims to create therapies targeting metabolic and regulatory imbalances.
Objective
Metabolic disorders are a major burden on the European population and health care systems. Moreover, metabolic perturbations contribute substantially to other pathologies such as neurodegenerative disorders and cancer. The causes of metabolic dysregulation are manifold and lead to pathological shifts, often in response to imbalanced nutrition. Likewise, changes in metabolism affect signalling mechanisms and gene regulation, aggravating the pathology. The mechanisms of this interdependence between metabolism and signalling are still not well understood. HubMOL will fill this knowledge gap and open new horizons by exploring the functional duality of a set of small molecules that are involved in all cellular functions - the Hub Molecules Of Life (HubMOLs) including ATP, SAM (S-adenosylmethionine) and the vitamin-derived cofactors, NAD, FAD, and CoA. They are key components of both metabolism and signalling networks and are interconnected, for example, through their participation in posttranslational protein modifications (PTMs). The complexity of this emerging area requires interdisciplinary scientists equipped with comprehensive competences covering experimental, computational and systems biology as well as clinical medicine. Therefore, the main HubMOL goal is to provide world-class training in these areas to 16 DCs enabling them to establish fundamentally new insights into cofactor biology and lay the ground for patient-tailored vitamin supplementation concepts. The strategic exposure of the 16 young researchers to leading European academic institutions, companies and clinical environments combined with systematic training in entrepreneurship and transferable skills will strongly improve their employability for positions in both private and public sectors. HubMOL will impact patients and society by developing therapies for metabolic and regulatory imbalances based on hub molecule biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences economics and business business and management entrepreneurship
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences nutrition
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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9019 Tromso
Norway
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Participants (12)
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5020 Bergen
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08916 Badalona
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9713 GZ Groningen
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Participation ended
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6020 Innsbruck
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04109 Leipzig
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1165 KOBENHAVN
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00185 Roma
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45147 Essen
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0164 Oslo
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2342 DH Leiden
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2950 VEDAEK
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82152 PLANEGG- MARTINSRIED
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Partners (8)
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1800 Vevey
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60487 Frankfurt Am Main
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1130 Wien
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80539 Planegg
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08193 Cerdanyola Del Valles
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81100 Caserta
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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9712CP Groningen
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