Project description
Bioengineered cornea to replace donor grafts
Diseases impacting the cornea, the transparent part of the eye, often require transplantation. However, the shortage of donor tissue and the risk of immune rejection limit transplantation success. Regenerative medicine has emerged as a promising alternative, enabling the fabrication of tissues that closely replicate native human organs. With the support of the Marie Skłodowska-Curie Actions programme, the MIMECOR project aims to engineer an artificial cornea through 3D printing techniques and stem cell technology. This strategy aims to recapitulate the structure and function of the cornea, thereby addressing key limitations associated with current therapies. Ultimately, MIMECOR has the potential to improve patient outcomes and reduce dependence on corneal transplants.
Objective
MIMECOR aims to develop an artificial and biomimetic cornea to achieve a major improvement in the quality of life of corneal disease patients, reducing their dependence on corneal transplants. This will be reached through the preparation and further modifications of a human-like cornea through the combination of additive manufacturing, stem cell transdifferentiation, and colonisation as an alternative to natural cornea donation. This approach is going to be a major breakthrough in Ophthalmology, as it will overcome the existing limitations of current treatments: it could become a reference in the therapy for specific corneal pathologies. The candidate researcher, Dr. Marć will provide to the project with her broad experience in applied preclinical research, gained in academic and industrial research groups of different European countries. She will learn cutting-edge techniques in Regenerative Medicine applied to Ophthalmology, through the interaction with a multidisciplinary, collaborative, and creative environment with specialists in engineering, medicine, physics, biology, and biochemistry. The candidate will perfect research skills such as experimental design, scientific writing, open science and data analysis. Moreover, through diverse training activities and a non-academic placement at a small-medium enterprise (the largest monographic ophthalmological private hospital in Europe), Dr. Marć will also acquire transferable skills and experience in grant implementation, ethics in Responsible Research and Innovation, time management, and scientific communication and divulgation. Besides, this formative plan accommodates her needs with the capabilities of the hosting group and institution. All this knowledge and skills will be crucial for the career success of the researcher. Due to her knowledge of the local language, Dr. Marć intends to become an established biomedical scientist in Spain after MSCA-PF, applying for Spanish postdoctoral grants and positions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28046 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.