Project description
Reprogramming immune cells to heal the heart
After a heart attack, the immune system plays a vital role in recovery by clearing damaged tissue and beginning the repair process. However, if inflammation lasts too long or is not properly regulated, it can cause damage. With the support of the Marie Skłodowska-Curie Actions programme, the 3MI project will investigate how the metabolism of key immune cells such as monocytes shapes their role in healing or damaging cardiac tissue. To identify pathways that control inflammation, researchers will track metabolic changes over time. The rationale is to modulate monocyte metabolism for improved heart repair and new treatments for cardiovascular diseases.
Objective
Cardiovascular diseases (CVD), particularly myocardial infarction (MI), are partly driven by chronic inflammation, in which myeloid cells, such as monocytes and macrophages, play a central role. This project aims to elucidate the metabolic mechanisms regulating monocyte function and their impact on post-MI recovery. Emerging evidence suggests that the metabolic state of myeloid progenitor cells and their descendants critically influences their pro- or anti-inflammatory functions. While glycolysis dominates early after MI, fatty acid oxidation takes over later stages, indicating that metabolic reprogramming is essential for monocyte and macrophage function.
In this project, we will investigate the metabolic signatures of monocytes at different time points post-MI using a preclinical mouse model and the human HIBISCUS STEMI cohort. We aim to identify key metabolic pathways that can be targeted to modulate inflammation by employing single-cell RNA sequencing and single-cell metabolic assays. In mouse models, we will further test the effects of transiently inhibiting glycolysis or fatty acid oxidation in monocytes, using genetically modified mice, to determine whether this approach improves cardiac function and limits heart failure.
Additionally, the fellowship will provide essential soft skills training in project management, mentoring, and grant writing, which are crucial for my transition to an independent research position. These skills will enhance my leadership abilities and prepare me for future academic and industrial opportunities.
This research will provide new insights into the role of metabolism in myelopoiesis and inflammation and could lead to novel therapeutic strategies to improve outcomes in CVD patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69002 Lyon
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.