Project description
Training future experts in neuroinflammation and neurodegeneration
Anti-IgLON5 disease is a recently identified neurological condition that combines features of autoimmunity and neurodegeneration. It is characterised by antibodies against the neuronal adhesion protein IgLON5 and is associated with severe sleep and movement disorders, as well as poor response to immunotherapy. Understanding this complex disease could unlock insights into a range of neurodegenerative disorders. With the support of the Marie Skłodowska-Curie Actions programme, the IGNITION project will train doctoral researchers to study the biology of anti-IgLON5 disease, improve its diagnosis and understand its association with inflammation-driven neurodegeneration. Researchers will develop new models, tools, and strategies to improve patient care.
Objective
Anti-IgLON5 disease is a recently described encephalopathy associated with a variety of neurological symptoms that can be life-threating. The clinical course is mainly chronic and the response to immunotherapies is suboptimal. The hallmark of the disease is the presence of antibodies against IgLON5, a cell adhesion molecule predominantly expressed on the neuronal membrane. Surprisingly, neuropathological findings on autopsies revealed the presence of an atypical neuronal brainstem tauopathy, establishing a link between neurodegeneration and IgLON5 antibodies. IGNITION aims to establish an innovative, interdisciplinary doctoral training program to foster the next generation of scientists at the interface of neuroinflammation and neurodegeneration. The unique program will train 13 Doctoral Candidates across four key objectives: 1) addressing clinical challenges in diagnosing and managing anti-IgLON5 disease, 2) investigating the role of neuroinflammation in neurodegeneration, 3) developing animal models for therapeutic testing, and 4) analysing the function of IgLON5 in health and disease. These objectives will be pursued using cutting-edge molecular, cellular, and in vivo techniques, offering a comprehensive research training experience with the support of leading biotech and diagnostic companies. IGNITION will advance our understanding of the mechanisms behind anti-IgLON5 disease, contributing to scientific innovation and providing tools for improved diagnosis and prognosis. The gained insights will extend to the broader field of neurodegeneration, offering potential breakthroughs for other tauopathies, including Alzheimer’s and Parkinson’s disease. Through its research and training activities, IGNITION will foster scientific excellence, increase disease awareness, and provide societal and economic benefits through the development of new diagnostic and therapeutic strategies across Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08036 Barcelona
Spain
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Participants (9)
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1090 Wien
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23562 Lübeck
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3015 GD Rotterdam
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20157 Milano
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75794 Paris
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3004-531 Coimbra
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07747 Jena
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50-370 Wroclaw
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08030 Barcelona
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Partners (13)
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28760 Tres Cantos
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08940 Cornella de Llobregat
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23560 Lubeck
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YO17 7DT Malton
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B-9052 Zwijnaarde
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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08860 Castelldefels
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69117 Heidelberg
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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65191 Wiesbaden
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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08007 Barcelona
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20072 PIEVE EMANUELE
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24118 Kiel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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33000 Bordeaux
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08036 Barcelona
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.