Objective
Cancer remains a leading cause of mortality, with over 90% of drug candidates failing clinical translation, often due to systemic toxicity from non-specific delivery. Magnetic helical microrobots (H-MMRs) offer a promising solution by enabling remote-controlled, minimally invasive navigation and localized drug release. However, their clinical translation is severely limited by speed: current H-MMRs achieve locomotion comparable to E. coli (~5–10 body lengths/s), far below high-performing microorganisms (~200–500 bl/s), and are unable to navigate millimetre-scale vessels under physiologically relevant blood flow (>10 cm/s). This speed limitation stems from the step-out frequency (ω_step-out), beyond which hydrodynamic drag overwhelms magnetic torque, leading to loss of synchronization.This project aims to overcome this barrier by establishing a material–structure synergistic design paradigm for high-speed H-MMRs (Hi-HMRs). Specifically, I will (i) enhance magnetic torque via 3D nanopatterning of biocompatible Fe-based soft magnetic alloys, exploiting focused electron beam-induced deposition (FEBID) for sub-100 nm precision; (ii) investigate nanoscale 3D spin textures in helical structures using advanced magneto-optical and synchrotron-based techniques (3D-MOKE, XMCD-PEEM) combined with micromagnetic simulations to optimize torque generation; and (iii) develop a novel magneto–fluid–structure interaction (MFSI) framework that integrates 3D magnetic topology with fluidic drag modelling, enabling rational co-design of helical geometry and material properties.By pushing the operational limits of H-MMRs beyond current step-out constraints, this research will deliver fundamental insights into high-speed microscale propulsion, while laying the technological foundation for their use in targeted intravascular therapies. The project addresses key MSCA priorities by advancing interdisciplinary science, fostering innovation, and contributing to biomedical technologies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences mathematics pure mathematics topology
- medical and health sciences clinical medicine oncology
- natural sciences mathematics pure mathematics geometry
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1040 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.