Obiettivo Short description of the additional proposal The main objectives of this proposal are the discovery and structural characterization of the MHC class II epitopes and superantigens that seem to be implicated in the development of Juvenile Rheumatoid Arthritis (JRA) and others autoimmune pathologues initiated by streptococcal M proteins. For this reason a principally new method and software for comparative protein structure ana molecular mimicry studies will be elaborated based on the amino acid codon root code ( the second half of the genetic code ). The new methods will be used for studies of structural and functional organization of M proteins ( Ml,M5,M6,M24,M49 etc.), other bacterial and viral superantigens and MHC class II proteins (HLADR, -DQ, -DP etc.) and also tissue specific proteins. Attempts will be made to identify (i) the locations of M proteins superantigenic sites involved in JRA pathology, (ii) the locations of M protein epitopes shared with protein of human miocardium and (iii) to test the hypothesis that functionally important epitopes have structutal elements characteristic for HLA - chain active site (region including amino acid 65-95). On the basis of obtained analitical data the design and synthesis of model peptides corresponding to revealed superantigenic and antigenic sites are envisaged. Attempts using model peptides to induce symptoms characteristic for the superantigen action and JRA autoimmune pathology will be made (in cooperation with other participants of the present project abroad). Programma(i) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Argomento(i) 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSIDAD COMPLUTENSE DE MADRID Contributo UE Nessun dato Indirizzo S/N,Plaza Ramon y Cajal S/N 28040 MADRID Spagna Mostra sulla mappa Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Institute of Inorganic Chemistry - Latvian Academy of Sciences Lettonia Contributo UE Nessun dato Indirizzo 34,Miera Iela 2169 Riga - Salaspils Mostra sulla mappa Costo totale Nessun dato
