Objective
Research objectives and content
The objectives of the research new glycosidases with specificity for the creation of B1->3, 1->4, or or 1->6 linkages to lactosamine derivatives from N-acetylglucosamine to create linkage types of importance in glycobiology. An approach combining detection of specific hydrolytic activity towards the target Resonance Mass Spectrometry (FTICRMS) will be developed. Enzymes detected by the hydrolytic mode of screening will then be tested for their synthetic capabilities, again using
fluorescence-tagged substrates with FTICR-MS confirmation of product structures.
Training content (objective, benefit and expected impact)
I will receive training in novel assay methods for the discovery of glycosidases useful for the synthesis of complex carbohydrates. The project will also give me experience in conventional chemical methods for oligosaccharide synthesis and in many advanced analytical techniques, particularly FTICR-MS.
Links with industry / industrial relevance (22)
The project will be of great interest to workers in glycobiology interested in the role of the glycosyl components of glycoproteins, many of which are in industrial laboratories. The host group at Warwick has extensive links with industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences theoretical physics particle physics particle accelerator
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CV4 7AL COVENTRY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.