Skip to main content
Przejdź do strony domowej Komisji Europejskiej (odnośnik otworzy się w nowym oknie)
polski pl
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
Zawartość zarchiwizowana w dniu 2024-04-30

Chemo-enzymatic synthesis of complex carbohydrates - discovery of new enzymes using fluorescence-tagged substrates and fourier transform ion cyclotron resonance mass spectrometry

Cel



Research objectives and content
The objectives of the research new glycosidases with specificity for the creation of B1->3, 1->4, or or 1->6 linkages to lactosamine derivatives from N-acetylglucosamine to create linkage types of importance in glycobiology. An approach combining detection of specific hydrolytic activity towards the target Resonance Mass Spectrometry (FTICRMS) will be developed. Enzymes detected by the hydrolytic mode of screening will then be tested for their synthetic capabilities, again using
fluorescence-tagged substrates with FTICR-MS confirmation of product structures.
Training content (objective, benefit and expected impact)
I will receive training in novel assay methods for the discovery of glycosidases useful for the synthesis of complex carbohydrates. The project will also give me experience in conventional chemical methods for oligosaccharide synthesis and in many advanced analytical techniques, particularly FTICR-MS.
Links with industry / industrial relevance (22)
The project will be of great interest to workers in glycobiology interested in the role of the glycosyl components of glycoproteins, many of which are in industrial laboratories. The host group at Warwick has extensive links with industry.

Dziedzina nauki (EuroSciVoc)

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

Brak dostępnych danych

System finansowania

RGI - Research grants (individual fellowships)

Koordynator

UNIVERSITY OF WARWICK
Wkład UE
Brak danych
Adres
Gibbet Hill
CV4 7AL COVENTRY
Zjednoczone Królestwo
Koszt całkowity
Brak danych

Uczestnicy (1)