Obiettivo Epilepsies represent a serious medical and social problem. Defects in a cysteineproteinase inhibitor, cystitis B (CSTB) gene were found by one Contractor to be responsible for progressive cyclones epilepsy of Unverricht-Lundborg type (EPM1)-an autosomal recessive neurodegenerative disease. We will use in vitro and in vivo approaches to understand the mechanisms by which deficiency of CSTB leads to the human disease. The current hypothesis is that deficiency of CSTB promotes neuronal apoptosis. We will develop a diagnostic test based on CSTB protein detection that is faster, cheaper and more reliable than the current DNA-based test. Unravelling the role and mechanisms of CSTB in cell death will allow the development of new and improved treatments that would result in considerable progress in the management of EPM1 patients by improving the quality of life of the individuals concerned by delaying or preventing the onset of disease. Campo scientifico medical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinssocial sciencessociologysocial issues Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-9. - Neurosciences Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF KUOPIO Contributo UE Nessun dato Indirizzo 9,Savilahdentie 9 G, 2nd floor 70210 KUOPIO Finlandia Mostra sulla mappa Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ISTITUTO NAZIONALE NEUROLOGICO 'CARLO BESTA' Italia Contributo UE Nessun dato Indirizzo Via Celoria 11 20133 MILANO Mostra sulla mappa Costo totale Nessun dato MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG Germania Contributo UE Nessun dato Indirizzo Universitaetsplatz 10 06099 HALLE (SAALE) Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF HELSINKI Finlandia Contributo UE Nessun dato Indirizzo 3,Haartmaninkatu 3 00014 HELSINKI Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF TARTU Estonia Contributo UE Nessun dato Indirizzo Uelikooli Str. 18 EE-50090 TARTU Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF TURKU Finlandia Contributo UE Nessun dato Indirizzo Kiinamyllynkatu 13 20014 TURKU Mostra sulla mappa Costo totale Nessun dato UPPSALA UNIVERSITY Svezia Contributo UE Nessun dato Indirizzo Sankt Olofsgatan 10 B 75105 UPPSALA Mostra sulla mappa Costo totale Nessun dato
